GrippeEspagneV1, Main, Exploration, bibRecord, 000128

Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.

Identifieur interne : 000128 ( Main/Exploration ); précédent : 000127; suivant : 000129

Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.

Auteurs : Esther Tamayo [Espagne] ; Milagrosa Montes [Espagne] ; Diego Vicente [Espagne] ; Emilio Pérez-Trallero [Espagne]

Source :

PloS one [ 1932-6203 ] ; 2016.

RBID : pubmed:27027618

Descripteurs français

KwdFr :
- Adulte (MeSH), Antigènes bactériens (génétique), Espagne (épidémiologie), Femelle (MeSH), Génotype (MeSH), Humains (MeSH), Infections à streptocoques (anatomopathologie), Infections à streptocoques (génétique), Infections à streptocoques (mortalité), Infections à streptocoques (physiopathologie), Mortalité (MeSH), Mâle (MeSH), Pneumopathie bactérienne (anatomopathologie), Pneumopathie bactérienne (génétique), Pneumopathie bactérienne (mortalité), Pneumopathie bactérienne (physiopathologie), Protéines de la membrane externe bactérienne (génétique), Protéines de transport (génétique), Streptococcus pyogenes (génétique), Streptococcus pyogenes (isolement et purification), Études rétrospectives (MeSH).
MESH :
- anatomopathologie : Infections à streptocoques, Pneumopathie bactérienne.
- génétique : Antigènes bactériens, Infections à streptocoques, Pneumopathie bactérienne, Protéines de la membrane externe bactérienne, Protéines de transport, Streptococcus pyogenes.
- isolement et purification : Streptococcus pyogenes.
- mortalité : Infections à streptocoques, Pneumopathie bactérienne.
- physiopathologie : Infections à streptocoques, Pneumopathie bactérienne.
- épidémiologie : Espagne.
- Adulte, Femelle, Génotype, Humains, Mortalité, Mâle, Études rétrospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adult (MeSH), Antigens, Bacterial (genetics), Bacterial Outer Membrane Proteins (genetics), Carrier Proteins (genetics), Female (MeSH), Genotype (MeSH), Humans (MeSH), Male (MeSH), Mortality (MeSH), Pneumonia, Bacterial (genetics), Pneumonia, Bacterial (mortality), Pneumonia, Bacterial (pathology), Pneumonia, Bacterial (physiopathology), Retrospective Studies (MeSH), Spain (epidemiology), Streptococcal Infections (genetics), Streptococcal Infections (mortality), Streptococcal Infections (pathology), Streptococcal Infections (physiopathology), Streptococcus pyogenes (genetics), Streptococcus pyogenes (isolation & purification).
MESH :
- chemical , genetics : Antigens, Bacterial, Bacterial Outer Membrane Proteins, Carrier Proteins.
- geographic , epidemiology : Spain.
- genetics : Pneumonia, Bacterial, Streptococcal Infections, Streptococcus pyogenes.
- isolation & purification : Streptococcus pyogenes.
- mortality : Pneumonia, Bacterial, Streptococcal Infections.
- pathology : Pneumonia, Bacterial, Streptococcal Infections.
- physiopathology : Pneumonia, Bacterial, Streptococcal Infections.
- Adult, Female, Genotype, Humans, Male, Mortality, Retrospective Studies.

Abstract

INTRODUCTION

In the preantibiotic era Streptococcus pyogenes was a common cause of severe pneumonia but currently, except for postinfluenza complications, it is not considered a common cause of community-acquired pneumonia in adults.

AIM AND MATERIAL AND METHODS

This study aimed to identify current clinical episodes of S. pyogenes pneumonia, its relationship with influenza virus circulation and the genotypes of the involved isolates during a decade in a Southern European region (Gipuzkoa, northern Spain). Molecular analysis of isolates included emm, multilocus-sequence typing, and superantigen profile determination.

RESULTS

Forty episodes were detected (annual incidence 1.1 x 100,000 inhabitants, range 0.29-2.29). Thirty-seven episodes were community-acquired, 21 involved an invasive infection and 10 developed STSS. The associated mortality rate was 20%, with half of the patients dying within 24 hours after admission. Influenza coinfection was confirmed in four patients and suspected in another. The 52.5% of episodes occurred outside the influenza seasonal epidemic. The 67.5% of affected persons were elderly individuals and adults with severe comorbidities, although 13 patients had no comorbidities, 2 of them had a fatal outcome. Eleven clones were identified, the most prevalent being emm1/ST28 (43.6%) causing the most severe cases.

CONCLUSIONS

S. pyogenes pneumonia had a continuous presence frequently unrelated to influenza infection, being rapidly fatal even in previously healthy individuals.

DOI: 10.1371/journal.pone.0152640
PubMed: 27027618
PubMed Central: PMC4814053

Affiliations:

Espagne

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00140
to stream Main, to step Curation: 000140

Le document en format XML

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<term>Carrier Proteins (genetics)</term>
<term>Female (MeSH)</term>
<term>Genotype (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Mortality (MeSH)</term>
<term>Pneumonia, Bacterial (genetics)</term>
<term>Pneumonia, Bacterial (mortality)</term>
<term>Pneumonia, Bacterial (pathology)</term>
<term>Pneumonia, Bacterial (physiopathology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Streptococcal Infections (genetics)</term>
<term>Streptococcal Infections (mortality)</term>
<term>Streptococcal Infections (pathology)</term>
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<term>Infections à streptocoques (génétique)</term>
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<term>Bacterial Outer Membrane Proteins</term>
<term>Carrier Proteins</term>
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<term>Pneumopathie bactérienne</term>
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<term>Pneumopathie bactérienne</term>
<term>Protéines de la membrane externe bactérienne</term>
<term>Protéines de transport</term>
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<term>Pneumopathie bactérienne</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>In the preantibiotic era Streptococcus pyogenes was a common cause of severe pneumonia but currently, except for postinfluenza complications, it is not considered a common cause of community-acquired pneumonia in adults.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>AIM AND MATERIAL AND METHODS</b>
</p>
<p>This study aimed to identify current clinical episodes of S. pyogenes pneumonia, its relationship with influenza virus circulation and the genotypes of the involved isolates during a decade in a Southern European region (Gipuzkoa, northern Spain). Molecular analysis of isolates included emm, multilocus-sequence typing, and superantigen profile determination.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Forty episodes were detected (annual incidence 1.1 x 100,000 inhabitants, range 0.29-2.29). Thirty-seven episodes were community-acquired, 21 involved an invasive infection and 10 developed STSS. The associated mortality rate was 20%, with half of the patients dying within 24 hours after admission. Influenza coinfection was confirmed in four patients and suspected in another. The 52.5% of episodes occurred outside the influenza seasonal epidemic. The 67.5% of affected persons were elderly individuals and adults with severe comorbidities, although 13 patients had no comorbidities, 2 of them had a fatal outcome. Eleven clones were identified, the most prevalent being emm1/ST28 (43.6%) causing the most severe cases.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>S. pyogenes pneumonia had a continuous presence frequently unrelated to influenza infection, being rapidly fatal even in previously healthy individuals.</p>
</div>
</front>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">In the preantibiotic era Streptococcus pyogenes was a common cause of severe pneumonia but currently, except for postinfluenza complications, it is not considered a common cause of community-acquired pneumonia in adults.</AbstractText>
<AbstractText Label="AIM AND MATERIAL AND METHODS" NlmCategory="UNASSIGNED">This study aimed to identify current clinical episodes of S. pyogenes pneumonia, its relationship with influenza virus circulation and the genotypes of the involved isolates during a decade in a Southern European region (Gipuzkoa, northern Spain). Molecular analysis of isolates included emm, multilocus-sequence typing, and superantigen profile determination.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Forty episodes were detected (annual incidence 1.1 x 100,000 inhabitants, range 0.29-2.29). Thirty-seven episodes were community-acquired, 21 involved an invasive infection and 10 developed STSS. The associated mortality rate was 20%, with half of the patients dying within 24 hours after admission. Influenza coinfection was confirmed in four patients and suspected in another. The 52.5% of episodes occurred outside the influenza seasonal epidemic. The 67.5% of affected persons were elderly individuals and adults with severe comorbidities, although 13 patients had no comorbidities, 2 of them had a fatal outcome. Eleven clones were identified, the most prevalent being emm1/ST28 (43.6%) causing the most severe cases.</AbstractText>
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<ForeName>Esther</ForeName>
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<ForeName>Milagrosa</ForeName>
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<AffiliationInfo><Affiliation>Biomedical Research Center Network for Respiratory Diseases (CIBERES), San Sebastián, Spain.</Affiliation>
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<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Vicente</LastName>
<ForeName>Diego</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Biomedical Research Center Network for Respiratory Diseases (CIBERES), San Sebastián, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez-Trallero</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Biomedical Research Center Network for Respiratory Diseases (CIBERES), San Sebastián, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Microbiology Department, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Medicine Faculty, University of the Basque Country, UPV/EHU, San Sebastián, Spain.</Affiliation>
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Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.

Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.

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